Leopard geckos hatch at a length of 6.5 to 8.5 cm (2.6 to 3.3 inches) and weighing approximately 3 grams. An adult of this species can reach a length of 20.5 to 27.5 cm (8.1 to 11 inches) and a weight of 54-65 grams.

Leopard geckos have tough skin around their back, neck and head, well suited to move on rocky terrain in a dry environment. Like all reptiles, they shed this skin periodically to allow for further growth.